4CYTE Horse Epiitalis Forte - what's in your horse's supplement


Interpath's 4CYTE Horse Epiitalis Forte is marketed as a fast acting, readily bioavailable joint supplement that helps reduce recovery times after exercise, assists older horses whilst also giving great care for young and growing horses.

What's in 4CYTE Horse Epiitalis Forte?

The ingredients are listed as:


Soya Oil Gel

Natural Apple flavouring

So, what is Epiitalis?

Epiitalis is a hydrolyzed oil extract made from the seeds of an evergreen coniferous tree Biota orientalis patented by the manufacturers of 4CYTE Interpath PTY Ltd. 

Biota orientalis, scientific name Platycladus orientalis, also known as Chinese thuja, (it's a native of North West China,) Chinese aborvitae, Oriental aborvitae and Bai Zi Ren has been used for thousands of years in traditional Chinese Medicine. It is considered one of the 50 fundamental herbs of TCM which uses the twigs, leaves and seeds to treat a huge variety of medical conditions ranging from coughs to internal bleeding to hair loss to pain control to anxiety. Apparently it's also used as a fragrance in men's colognes!

The patented seed extract Epiitalis is used in the treatment of  both human and animal osteoarthritis.

Does Epiitalis work?

Clinical trials examining the effects of oral supplement Biota orientalis in the osteochondral fragment -exercise model of osteoarthritis in horses found "significant reduction in radiographic scores for subchondral lysis of the radial carpal bone, osteophyte formation, subchondral sclerosis of the radial carpal bone and total radiographic score for horses treated with BO."  

(source: https://pubmed.ncbi.nlm.nih.gov/35720848/)

A 2019/2020 human clinical trial with 237 participants aged between 40 & 65 years old to establish the role of Epiitalis as a single ingredient in the treatment of mild to moderate cases of knee osteoarthritis found it was safe and efficacious at reducing symptoms in patients with knee OA.

 (source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216293/ )

A randomised control masked trial of 4CYTE Canine compared to the NSAID Carprofen licensed for the treatment of  osteoarthritis in dogs concluded that 4CYTE Canine was not inferior to Carprofen

(source: https://pubmed.ncbi.nlm.nih.gov/33904159/)

What our ponyhour reviewer says:

" I confess to singing the praises of 4CYTE to anyone who will listen to me! 

My horse had sacroiliac problems, he's had steroid injections, acupuncture and sees the "back lady" every month. I was advised to put him on a joint supplement, unfortunately he had a bad reaction to the green lipped mussel one that I was recommended, he coliced and I had to have the emergency vet out to him. Therefore it was important for me to find a joint supplement completely free from animal ingredients. I was relieved to find 4CYTE Horse Epiitalis Forte and have been delighted with the results, it works for him (and me)."